Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder

Author:

Trzaskowski Maciej1ORCID,Mehta Divya12,Peyrot Wouter J.3,Hawkes David4,Davies Daniel5,Howard David M.6ORCID,Kemper Kathryn E.1,Sidorenko Julia1,Maier Robert17,Ripke Stephan8910,Mattheisen Manuel1112,Baune Bernhard T.13,Grabe Hans J.14,Heath Andrew C.15,Jones Lisa16,Jones Ian17,Madden Pamela A.F.15,McIntosh Andrew M.618,Breen Gerome1920,Lewis Cathryn M.1921,Børglum Anders D.1222,Sullivan Patrick F.232425,Martin Nicholas G.26ORCID,Kendler Kenneth S.27ORCID,Levinson Douglas F.28,Wray Naomi R.129ORCID,

Affiliation:

1. Institute for Molecular Bioscience; The University of Queensland; Brisbane Queensland Australia

2. School of Psychology and Counselling; Queensland University of Technology; Brisbane Australia

3. Department of Psychiatry; Vrije Universiteit Medical Center and GGZ in Geest; Amsterdam The Netherlands

4. AGRF; The University of Queensland; Brisbane Queensland Australia

5. Department of Psychiatry, Behavioural and Clinical Neuroscience Institute and Developmental Psychiatry; Cambridge University; Cambridge England United Kingdom

6. Division of Psychiatry; University of Edinburgh; Edinburgh United Kingdom

7. Analytic and Translational Genetics Unit; Massachusetts General Hospital and Harvard Medical School; Boston Massachusetts

8. Medical and Population Genetics; Broad Institute; Cambridge Massachusetts

9. Analytic and Translational Genetics Unit; Massachusetts General Hospital; Boston Massachusetts

10. Department of Psychiatry and Psychotherapy; Universitätsmedizin Berlin Campus Charité Mitte; Berlin Germany

11. Department of Biomedicine; Aarhus University; Aarhus Denmark

12. iPSYCH; The Lundbeck Foundation Initiative for Integrative Psychiatric Research; Aarhus Denmark

13. Department of Psychiatry; The University of Melbourne; Melbourne Victoria Australia

14. Department of Psychiatry and Psychotherapy; University Medicine Greifswald; Greifswald Germany

15. Department of Psychiatry; Washington University in Saint Louis School of Medicine; Saint Louis Missouri

16. Institute of Health & Society; University of Worcester; Worcester United Kingdom

17. MRC Centre for Neuropsychiatric Genetics and Genomics; Cardiff University; Cardiff United Kingdom

18. Centre for Cognitive Ageing and Cognitive Epidemiology; University of Edinburgh; Edinburgh United Kingdom

19. MRC Social Genetic and Developmental Psychiatry Centre; King's College London; London United Kingdom

20. NIHR BRC for Mental Health; King's College London; London United Kingdom

21. Department of Medical and Molecular Genetics; King's College London; London United Kingdom

22. Department of Biomedicine and iSEQ-Centre for Integrative Sequencing; Aarhus University; Aarhus Denmark

23. Department of Medical Epidemiology and Biostatistics; Karolinska Institutet; Stockholm Sweden

24. Department of Genetics; University of North Carolina at Chapel Hill; Chapel Hill North Carolina

25. Department of Psychiatry; University of North Carolina at Chapel Hill; Chapel Hill North Carolina

26. Genetics and Computational Biology; QIMR Berghofer Medical Research Institute; Brisbane Queensland Australia

27. Department of Psychiatry; Virginia Commonwealth University; Richmond Virginia

28. Psychiatry and Behavioral Sciences; Stanford University; Stanford California

29. Queensland Brain Institute; The University of Queensland; Brisbane Queensland Australia

Funder

National Health & Medical Research Council

Publisher

Wiley

Subject

Cellular and Molecular Neuroscience,Psychiatry and Mental health,Genetics(clinical)

Reference51 articles.

1. Analysis of shared heritability in common disorders of the brain;Anttila;Science,2018

2. Characterizing race/ethnicity and genetic ancestry for 100,000 subjects in the genetic epidemiology research on adult health and aging (GERA) cohort;Banda;Genetics,2015

3. Genome-wide association of major depression: Description of samples for the GAIN major depressive disorder study: NTR and NESDA biobank projects;Boomsma;European Journal of Human Genetics,2008

4. Social and physical health risk factors for first-onset major depressive disorder in a community sample;Bruce;Social Psychiatry and Psychiatric Epidemiology,1994

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