Development of a neuromedin U-human serum albumin conjugate as a long-acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide-Reference-Cited by-同舟云学术

Development of a neuromedin U-human serum albumin conjugate as a long-acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide

Published:2013-11-13 Issue:1 Volume:20 Page:7-19
ISSN:1075-2617
Container-title:Journal of Peptide Science
language:en
Short-container-title:J. Pept. Sci.

Author:

Neuner Philippe¹²,Peier Andrea M.³,Talamo Fabio¹⁴,Ingallinella Paolo¹⁵,Lahm Armin¹,Barbato Gaetano¹⁶,Di Marco Annalise¹⁷,Desai Kunal³,Zytko Karolina¹,Qian Ying³,Du Xiaobing³,Ricci Davide¹⁷,Monteagudo Edith¹⁷,Laufer Ralph¹⁷,Pocai Alessandro³⁸,Bianchi Elisabetta¹⁷,Marsh Donald J.³⁹,Pessi Antonello¹¹⁰¹¹

Affiliation:

1. IRBM P. Angeletti; 00040 Pomezia RM Italy

2. NIBR WSJ-507.1.02, Novartis Pharma AG, Campus; CH-4056 Basel Switzerland

3. Department of Metabolic Disorders; Merck Research Laboratories; Rahway NJ 07065 USA

4. Department of Biological Systems Research; Research & Development at Philip Morris Products S.A.; Quai Jean Renaud 5 CH 2000 Neuchatel Switzerland

5. DiaSorin Research Center; 21040 Gerenzano VA Italy

6. Department of Science and Chemical Technology; University of Tor Vergata; Rome Italy

7. IRBM Science Park; 00040 Pomezia RM Italy

8. Janssen R&D; 1577 Welsh Rd & Mckean Rd Spring House PA 19477 USA

9. Department of Safety Assessment and Laboratory Animal Resources; Merck Research Laboratories; Kenilworth NJ 07033-1310 USA

10. PeptiPharma; Viale Città D'Europa 679 00144 Rome Italy

11. CEINGE; Via Gaetano Salvatore 486 80145 Napoli Italy

Publisher

Wiley

Subject

Organic Chemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry,Structural Biology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/psc.2582/fullpdf

Reference58 articles.

1. Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway;Hanada;Nat. Med.,2004

2. Identification of receptors for neuromedin U and its role in feeding;Howard;Nature,2000

3. Central effects of neuromedin U in the regulation of energy homeostasis;Nakazato;Biochem. Biophys. Res. Commun.,2000

4. Neuromedin U and its receptors: structure, function, and physiological roles;Brighton;Pharmacol. Rev.,2004

5. Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S;Mitchell;Br. J. Pharmacol.,2009

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