Novel markers and networks related to restored skeletal muscle transcriptome after bariatric surgery

Author:

Ouni Meriem12ORCID,Kovac Leona12,Gancheva Sofiya234,Jähnert Markus12,Zuljan Erika12,Gottmann Pascal12,Kahl Sabine23,de Angelis Martin Hrabĕ256,Roden Michael234,Schürmann Annette127

Affiliation:

1. German Institute of Human Nutrition Department of Experimental Diabetology Potsdam Germany

2. German Center for Diabetes Research (DZD) Munich Germany

3. Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Heinrich Heine University Düsseldorf Germany

4. Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research Heinrich Heine University Düsseldorf Germany

5. Institute of Experimental Genetics, German Mouse Clinic Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg Germany

6. School of Life Sciences Technical University Munich Freising Germany

7. Institute of Nutritional Sciences University of Potsdam Nuthetal Germany

Abstract

AbstractObjectiveThe aim of this study was to discover novel markers underlying the improvement of skeletal muscle metabolism after bariatric surgery.MethodsSkeletal muscle transcriptome data of lean people and people with obesity, before and 1 year after bariatric surgery, were subjected to weighted gene co‐expression network analysis (WGCNA) and least absolute shrinkage and selection operator (LASSO) regression. Results of LASSO were confirmed in a replication cohort.ResultsThe expression levels of 440 genes differing between individuals with and without obesity were no longer different 1 year after surgery, indicating restoration. WGCNA clustered 116 genes with normalized expression in one major module, particularly correlating to weight loss and decreased plasma free fatty acids (FFA), 44 of which showed an obesity‐related phenotype upon deletion in mice. Among the genes of the major module, 105 represented prominent markers for reduced FFA concentration, including 55 marker genes for decreased BMI in both the discovery and replication cohorts.ConclusionsPreviously unknown gene networks and marker genes underlined the important role of FFA in restoring muscle gene expression after bariatric surgery and further suggest novel therapeutic targets for obesity.

Funder

Deutsche Forschungsgemeinschaft

Schmutzler Stiftung

Deutsche Diabetes Gesellschaft

Publisher

Wiley

Subject

Nutrition and Dietetics,Endocrinology,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3