Isoflavones from Placolobium vietnamense, an indigenous plant of Vietnam

Author:

Lien Do Thi My1,Tuyet Huynh Thi Ngoc2,Quyen Tran Hong Ngoc3ORCID,Truong Tuong Lam1,Hang Nguyen Thi Thu4,Thao Nguyen Thi Ngoc4,Dung Nguyen Thi My5

Affiliation:

1. Institute of Environment ‐ Energy Technology Sai Gon University, 273, An Duong Vuong Street, Distr. 5 Ho Chi Minh City 70000 Viet Nam

2. Lu Gia Junior High school 52/1A, Lu Gia, 15 Award, Distr. 11 Ho Chi Minh City 70000 Viet Nam

3. Hong Bang Junior High school 132 Hong Bai, 12 Award, Distr. 5 Ho Chi Minh City 70000 Viet Nam

4. Faculty of Environmental Sciences Sai Gon University 273, An Duong Vuong Street, Distr. 5 Ho Chi Minh City 70000 Viet Nam

5. Faculty of Natural Sciences Pedagogy Sai Gon University 273, An Duong Vuong Street, Distr. 5 Ho Chi Minh City 70000 Viet Nam

Abstract

AbstractPlacolobium vietnamense N.D.Khoi & Yakovlev (Fabaceae) is an indigenous plant of Vietnam. Up to now, this plant has not yet been chemically and biologically studied. In this paper, six isoflavones including afrormosin (1), cladrastin (2), 8‐O‐methylretusin (3), millesianin C (4), barbigerone (5), and durallone (6) were isolated from the ethyl acetate extract of the stem bark of Placolobium vietnamense. Their structures were established by means of physical data (ESI MS, 1D and 2D NMR) and evaluated for the cytotoxic activities against liver hepatocellular carcinoma (HepG2), human lung cancer (NCI‐H460), human epithelial carcinoma (HeLa) and human breast cancer (MCF‐7) cell lines. This is the first report on phytochemical studies of this plant.

Publisher

Wiley

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