Xestospongiene VN1, a new brominated polyunsaturated lipid from marine sponge Xestospongia testudinaria (Lamark, 1815)

Author:

Tai Bui Huu12,Hang Dan Thi Thuy1,Thung Do Cong3,Trang Do Thi1,Yen Pham Hai1,Yen Duong Thi Hai1,Huong Phan Thi Thanh1,Dung Duong Thi1,Cuong Ngo Cao14,Thao Do Thi5,Nhiem Nguyen Xuan12ORCID,Van Kiem Phan12

Affiliation:

1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi 10000 Viet Nam

2. Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi 10000 Viet Nam

3. Institute of Marine Environment and Resources, VAST 246 Danang Ngo Quyen, Hai phong Viet Nam

4. Vietnam ‐ Russia Tropical Centre Nguyen Van Huyen, Cau Giay, Hanoi 100000 Viet Nam

5. Institute of Biotechnology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi 10000 Viet Nam

Abstract

AbstractPhytochemical study on the methanol extract of the marine sponge Xestospongia testudinaria (Lamark, 1815) led to the isolation of one new ((6Z,8E,13E,15Z)‐6,14,16‐tribromo‐5,10‐dihydroxyhexadeca‐6,8,13,15‐tetraenoic acid named xestospongiene VN1, 1) and nine known brominated polyunsaturated compounds, xestospongiene z5 & z6 (2), xestospongiene z9 & z10 (3), xestospongiene S (4), xestospongic acid (5), xestospongic acid methyl ester (6), (13E,17E)‐18‐bromo‐octadeca‐13,17‐diene‐5,7,15‐triymoic acid (7), xestospongiene I & J (8), xestospongiene K & L (9), and xestospongiene C & D (10). The chemical structures of these compounds were elucidated by extensive spectroscopic analyses including HR‐ESI‐MS, 1D and 2D NMR, circular dichroism, and by comparison of the spectral data with those of previously reported data. This is the first report of these compounds from Vietnamese marine sponge X. testudinaria.

Publisher

Wiley

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