Synthesis of two indomethacin‐dimers with biological activity on heart failure-Reference-Cited by-同舟云学术

Synthesis of two indomethacin‐dimers with biological activity on heart failure

Published:2022-02 Issue:1 Volume:60 Page:37-48
ISSN:2572-8288
Container-title:Vietnam Journal of Chemistry
language:en
Short-container-title:Vietnam Journal of Chemistry

Author:

Lauro Figueroa‐Valverde¹,Francissco Diaz‐cedillo²,Marcela Rosas‐Nexticapa³,Maria López‐Ramos¹,Virginia Mateu‐Armad Maria³,Magdalena Alvarez‐Ramirez³,Tomas Lopez‐Gutierrez¹,Alejandra Garcimarrero‐Espino³

Affiliation:

1. Laboratory of Pharmaco‐Chemistry, Faculty of Chemical Biological Sciences, University Autonomous of Campeche Humberto Lanz Cárdenas S/N, Colonia Ex Hacienda Kalá, C.P 24085 Campeche México

2. Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, D.F.C.P. 11340 México

3. Facultad de Nutrición, Universidad Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz México

Abstract

AbstractThere are few studies for the preparation of dimers with biological activity. In this research, two indomethacin dimers were prepared from indomethacin and characterized by NMR spectroscopic methods. Then, biological activity produced by indomethacin dimers were evaluated on heart failure using a biological model. The results indicate that protocols used for synthesis of indomethacin dimers do not require special conditions to give a good yielding. Other data showed that indomethacin dimers decrease heart failure. In conclusion, indomethacin dimers would be good candidates for treating of heart failure.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/vjch.202100051

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