Synthesis of two 2,3,4,5‐tetrahydrooxepin‐7‐ylamino)benzoate derivatives as antibacterial agents against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>-Reference-Cited by-同舟云学术

Synthesis of two 2,3,4,5‐tetrahydrooxepin‐7‐ylamino)benzoate derivatives as antibacterial agents against Escherichia coli and Staphylococcus aureus

Published:2021-12 Issue:6 Volume:59 Page:923-934
ISSN:2572-8288
Container-title:Vietnam Journal of Chemistry
language:en
Short-container-title:Vietnam Journal of Chemistry

Author:

Maria López‐Ramos¹,Lauro Figueroa‐Valverde¹,Francisco Díaz‐Cedillo²,Ricardo Gobato³,Areza Heidari⁴,Marcela Rosas‐Nexticapa⁵,Virginia Mateu‐Armad Maria³,Magdalena Alvarez‐Ramirez⁵

Affiliation:

1. Laboratory of Pharmaco‐Chemistry, Faculty of Chemical Biological Sciences University Autonomous of Campeche Av. Agustín Melgar s/n, Col Buenavista C.P 24039 Campeche, Camp. México

2. Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, D.F. C.P. 11340 México

3. Green Land Landscaping and Gardening, Seedling Growth Laboratory Brazil

4. BioSpectroscopy Core Research Laboratory at Faculty of Chemistry California South University (CSU) Irvine, California

5. Facultad de Nutrición, Universidad Veracruzana, Médicos y Odontologos s/n C.P. 91010, Unidad del Bosque Xalapa Veracruz México

Abstract

AbstractSome protocols have been used to preparation of oxepine analogs using some substances which require special conditions such as higher‐temperatures or differences in the pH. The objective of this study was to synthesize two new oxepine‐derivatives from a Bicyclo[6.1.0]‐alkyne analog. Besides, the antibacterial effect against Escherichia coli and Staphylococcus aureus was determinate. The results showed that protocols used for synthesis of two oxepine analogs do not require special conditions to give a good yielding. Other data showed that oxepine analogs decreased the growth bacterial of Escherichia coli and Staphylococcus aureus. In conclusion, in this investigation a facile method for the synthesis of two oxepine derivatives is reported; in addition, these compounds could be good candidates as antibacterial reagents.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/vjch.202100095

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