Affiliation:
1. Graduate University of Science and Technology, Institute of Marine Biochemistry Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Cau Giay Hanoi 10072 Viet Nam
2. Faculty of Natural Sciences Quy Nhon University 170 An Duong Vuong, Nguyen Van Cu Quy Nhon Binh Dinh 55000 Viet Nam
3. Hong Duc University 565 Quang Trung Dong Ve Thanh Hoa 44000 Viet Nam
4. Faculty of Pharmacy Dai Nam University Phu Lam, Ha Dong Hanoi 10000 Viet Nam
Abstract
AbstractPhytochemical study of Knema pachycarpa leaves led to the isolation of ten compounds. Their chemical structures were determined as (7”R, 8”R)‐hydnocarpin D (1), (7”R, 8”R)‐hydnocarpin (2), sinaicitin (3), (‐)‐globulol (4), β‐caryolanol (5), phytol (6), biochanin A (7), chrysoeriol (8), tanoside II (9) and astragalin (10) using NMR and MS spectral data. Among the isolates, (7”R, 8”R)‐hydnocarpin (2) showed good cytotoxic activity against KB, HepG‐2, Lu and MCF‐7 cancer cell lines with IC50 values from 13.99±0.62 μg/mL to 30.65±1.44 μg/mL. Compound 4 showed selective cytotoxicity against LU cancer cell line and significant acetylcholinesterase (AChE) inhibition with IC50 values of 12.31±0.51 μg/mL and 5.12±0.22 μg/mL, respectively.