A facile synthesis, characterization and docking studies of 2‐methyl‐3‐(<scp>5‐phenyl‐4<i>H</i></scp>‐(1,2,4)triazol‐3‐yl)‐quinoxaline and its derivatives-Reference-Cited by-同舟云学术

A facile synthesis, characterization and docking studies of 2‐methyl‐3‐(5‐phenyl‐4H‐(1,2,4)triazol‐3‐yl)‐quinoxaline and its derivatives

Published:2022-02 Issue:1 Volume:60 Page:92-100
ISSN:2572-8288
Container-title:Vietnam Journal of Chemistry
language:en
Short-container-title:Vietnam Journal of Chemistry

Author:

Reddy S. Ramakrishna¹,Reddy G. Ganga¹,Reddy Ch. Venkata Ramana¹,Reddy B. Srinivasa²,Laxminarayana E.³

Affiliation:

1. Department of Chemistry Jawaharlal Nehru Technological University Hyderabad Kukatpally Hyderabad ‐500 085 India

2. Mahatma Gandhi Institute of Technology Kokapet, Gandipet, Hyderabad 500075 India

3. Sreenidhi Institute of Science and Technology (Autonomous) Yamnampet Ghatkesar Hyderabad ‐501301 India

Abstract

AbstractA new series of 2‐Methyl‐3‐(5‐phenyl‐4H‐(1,2,4)triazol‐3‐yl)‐quinoxaline derivatives have been synthesized by simple and efficient method by using 3‐methyl‐quinoxaline‐2‐carboxylic acid, 3‐methyl‐quinoxaline‐2‐carboxylicacidethylester and 3‐methyl‐quinoxaline‐2‐carboxylichydrazide as reaction intermediates in good yields. All the synthesized compounds were characterized by spectral and elemental analysis. The molecular docking studies of 2‐Methyl‐3‐(5‐phenyl‐4H‐(1,2,4)triazol‐3‐yl)‐quinoxalinecarried to predict the anti bacterial potential.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/vjch.202100090

Reference27 articles.

1. Design, synthesis, and biological evaluation of novel alkylsulfanyl-1,2,4-triazoles as cis-restricted combretastatin A-4 analogues

2. Design, synthesis and biological evaluation of flexible and rigid analogs of 4H-1,2,4-triazoles bearing 3,4,5-trimethoxyphenyl moiety as new antiproliferative agents

3. Synthesis, characterization, and in vivo pharmacological evaluation of novel mannich bases derived from 1,2,4-triazole containing a naproxen moiety

4. Synthesis and Pharmacological Potential of New 3-Mercapto-4-Amino(Pyrrolyl-1)-5-(Thienyl-2)-1,2,4-Triazole(4H) Derivatives

5. New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies