Affiliation:
1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi 10000 Viet Nam
2. Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi 10000 Viet Nam
3. Hanoi Amsterdam Highschool for the Gifted, Hoang Minh Giam Cau Giay Hanoi 10000 Viet Nam
4. Institute of Marine Environment and Resources, Vietnam Academy of Science and Technology 246 Da Nang Ngo Quyen, Hai Phong 18000 Viet Nam
Abstract
AbstractSeven compounds, dihydrosinularin (1), 11‐epi‐sinulariolide acetate (2), 10,18‐diacetoxydilabella‐2,7‐dien‐6‐one (3), 4‐(2′,3′,4′‐trimethylphenyl)‐but‐(3E)‐en‐2‐one (4), 4‐hydroxybenzaldehyde (5), indole‐3‐aldehyde (6), and methyl indole‐3‐carboxylate (7) were isolated from Clathria reinwardti. The isolates were identified by ESIMS, 1D and 2D NMR spectra. Compounds 1‐4 significantly exhibited the cytotoxic activity against SK‐LU‐1, MCF‐7, HepG2, and SK‐Mel‐2 cell lines with the IC50 values ranging from 3.8 ± 0.1 to 23.0 ± 0.2 μM, compared to the positive control compound (ellipticine, IC50, ranging from 1.4 ± 0.2 to 1.7 ± 0.1 μM). This is the first report of these compounds from C. reinwardti.
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2 articles.
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