Phytochemistry and anti‐inflammatory activity of iridoids from Dolichandrone spathacea collected in the mangrove forest of Phu Loc district, Thua Thien Hue province, Vietnam

Author:

Thao Tran Thi Phuong12,Chi Nguyen Linh12,Luu Nguyen Thi1,Dung Nguyen Thi1,Van Loc Tran12,Van Tuan Nguyen3ORCID,Hung Trieu Quy4,Nhung Nguyen Thi Ai

Affiliation:

1. Institute of Chemistry Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Road, Cau Giay Hanoi 10000 Viet Nam

2. Graduate University of Science and Technology VAST, 18 Hoang Quoc Viet Road, Cau Giay Hanoi 10000 Viet Nam

3. Asean college of Medicine and Pharmacy Trung Trac street, Van Lam district, Hung Yen province 17000 Viet Nam

4. Department of Chemistry University of Sciences Hue University, 77 Nguyen Hue, Phu Nhuan, Hue City 49000 Viet Nam

Abstract

AbstractFrom the leaves and barks of Dolichandrone spathacea collected in the mangrove forest of Hue province, three iridoids {6‐O‐[(E)‐4‐methoxy cinnamoyl]catalpol (1), 6‐O‐[(E)‐3,4‐dimethoxy cinnamoyl]catalpol (2), nemoroside (3)} and three ursane‐type triterpenoids [ursolic acid (4), pomolic acid (5), uncaric acid (6)] were isolated and structurally elucidated. Besides, succrose octaacetate (7), daucosterol tetraacetate (8) and 1‐hentriacontanol (9) were identified from the fruits of this mangrove species. It is the first time compounds 6, 7, 9 were isolated from Dolichandrone spathacea. The main constituents of this plant, iridoids 1 and 2, were tested for the inhibition of IL‐6, TNF‐α factors and NO production. The anti‐inflammatory activity as well as the phytochemistry of the fruits of this species are reported for the first time.

Publisher

Wiley

Reference19 articles.

1. Phytochemical analysis and antimicrobial evaluation of Dolichandrone spathacea (Bignoniaceae);Nguyen P. D.;Planta Med.,2016

2. Antimicrobial constituents from leaves of Dolichandrone spathacea and their relevance to traditional use;Nguyen P. D.;Planta Med.,2018

3. NguyenVan Tuan DoLe Quyen Nguyen The Anh Nguyen Tuan Thanh Tran Van Loc Ho Ngoc Anh Tran Van Chien Tran Van Sung Tran Thi Phuong Thao. New cycloartanes and new iridoids fromDolichandrone spathaceacollected in the mangrove forest of Soc Trang province Vietnam J. Asian Nat. Prod. Res. 2018 20(9) 889‐896.

4. Study on chemical constituents from the barks of Dolichandrone spathacea, Master thesis, Vietnam National University, Ho Chi Minh;Tri Le Minh;City,2011

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