CLPC1 protein inhibition, antimycobacterial, and anti‐inflammatory properties of the metabolite from <i>Streptomyces wuyuanensis</i> collected in Nghe An province, Vietnam-Reference-Cited by-同舟云学术

CLPC1 protein inhibition, antimycobacterial, and anti‐inflammatory properties of the metabolite from Streptomyces wuyuanensis collected in Nghe An province, Vietnam

Published:2024-02 Issue:1 Volume:62 Page:85-91
ISSN:2572-8288
Container-title:Vietnam Journal of Chemistry
language:en
Short-container-title:Vietnam Journal of Chemistry

Author:

Ni Huynh Thi Ngoc¹²,Ninh Pham Thi³,Dung Nguyen Thi³,Van Chien Tran³,Uyen Nguyen Quynh⁴,Anh Ho Ngoc⁵,Suh Joo‐Won⁶^ORCID,Cheng Jinhua⁶,Thao Nguyen Kim Nu⁷,Duc Nguyen Minh⁸,Thao Tran Thi Phuong¹³^ORCID

Affiliation:

1. Faculty of Chemistry Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST) Cau Giay Hanoi Vietnam

2. Faculty of Natural Sciences Phu Yen University Tuy Hoa city, Phu Yen Vietnam

3. Institute of Chemistry, Vietnam Academy of Science and Technology (VAST) Cau Giay Hanoi Vietnam

4. Laboratory for Applied Molecular Biology Institute of Microbiology and Biotechnology, Vietnam National University Cau Giay Hanoi Vietnam

5. Institute of Biotechnology, Vietnam Academy of Science and Technology (VAST) Cau Giay Hanoi Vietnam

6. Myongji Bioefficacy Research Center Myongji University, Yongin‐si, Gyeonggi‐do, Republic of Korea Yongin‐si Gyeonggi‐do Republic of Korea

7. Faculty of Biology University of Natural Science Vietnam National University Thanh Xuan Hanoi Vietnam

8. Institute of Genome Research, Vietnam Academy of Science and Technology Cau Giay Hanoi Vietnam

Abstract

AbstractStreptomyces wuyuanensis A79 was isolated from the soil samples collected in Quynh Luong mangrove forest, Quynh Luu district, Nghe An province, Vietnam. This strain demonstrated antimycobacterial activity against Mycobacterium smegmatis. Compound 1 (indole‐3‐carboxylic acid) was isolated from the culture extract of S. wuyuanensis (A79). This compound displayed the affection of ATPase activity of the recombinant ClpC1 protein, a regulatory protein of Mycobacterium tuberculosis. In addition, compound 1 exhibited anti‐inflammatory activity through the inhibition of TNF‐α on LPS‐stimulated macrophage RAW264.7. This is the first time compound 1 (indole‐3‐carboxylic acid) has been isolated from S. wuyuanensis. Indole‐3‐carboxylic acid was also reported for the first time its inhibition of M. tuberculosis ClpC1 protein.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/vjch.202300345

Reference33 articles.

1. Evolution of virulence in the Mycobacterium tuberculosis complex

2. World Health Organization:Global Tuberculosis report 2022.https://www.who.int/publications/i/item/9789240061729(accessed: Octocber 2022).

3. Recent advances in the treatment of tuberculosis;Motta I.;Clin. Microbiol. Infect.,2023

4. Practice regarding tuberculosis care among physicians at private facilities: A cross-sectional study from Vietnam

5. Effectiveness and safety of bedaquiline-based, modified all-oral 9–11-month treatment regimen for rifampicin-resistant tuberculosis in Vietnam