Affiliation:
1. Institute of Chemistry Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Road Cau Giay Hanoi 10000 Viet Nam
2. National Institute of Hygiene and Epidemiology 1 Yersin Street Hai Ba Trung Hanoi 10000 Viet Nam
3. Institute of Biotechnology Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Road Cau Giay Hanoi 10000 Viet Nam
4. Hanoi University of Medicine Nr. 1, Ton That Tung Street Kim Lien, Dong Da Hanoi 10000 Viet Nam
5. Graduate University of Science and Technology Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Road Cau Giay Hanoi 10000 Viet Nam
Abstract
AbstractThe ethanol extract from the leaves and twigs of Euphorbia cyathophora showed antiviral activity against four dengue virus serotypes (DENV1‐4), with PRNT50 values of 15.625‐62.5 μg/mL. Eight compounds including germanicol acetate (1), cymbopogone (2), 1‐heptacosanol (3), ethyl α‐L‐arabinofuranoside (4), quercetin (5), 3‐acetoxy‐5,7,3’,4’‐tetrahydroxyflavone (6), 3‐acetoxy‐5,7,4’‐trihydroxyflavone (7), 4’‐acetoxy‐3,5,7‐trihydroxyflavone (8) were isolated from this extract. Compounds 2‐8 were isolated for the first time from Euphorbia cyathophora. Antiviral activity evaluation of compounds 1‐3, 5‐7 on DENV1‐4 serotypes revealed that 7 was the most active compound with PRNT50 values of 23.8‐95.2 μM.
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