Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation
Author:
Affiliation:
1. Department of Oral Medicine, Infection, and Immunity; Harvard School of Dental Medicine; Boston MA USA
Funder
Funds from HSDM (to BL), Postdoctoral Fellowships for Research Abroad from Japan Society for the Promotion of Science (to KA)
Publisher
Wiley
Subject
Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism
Reference24 articles.
1. Regulatory mechanisms in the pathways of cartilage and bone formation;de Crombrugghe;Curr Opin Cell Biol,2001
2. Developmental regulation of the growth plate;Kronenberg;Nature,2003
3. Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1;Gao;Nat Genet,2001
4. Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips;Hellemans;Am J Hum Genet,2003
5. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation;St-Jacques;Genes Dev,1999
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