Acute Treatment With XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice-Reference-Cited by-同舟云学术

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Acute Treatment With XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice

Published:2015-07-23 Issue:9 Volume:116 Page:2109-2119
ISSN:0730-2312
Container-title:Journal of Cellular Biochemistry
language:en
Short-container-title:J. Cell. Biochem.

Author:

Bedinger Daniel H.¹²,Kieffer Dorothy A.³,Goldfine Ira D.¹,Roell Marina K.¹,Adams Sean H.²³⁴

Affiliation:

1. XOMA Corporation; Berkeley California

2. Molecular, Cellular and Integrative Physiology Graduate Group; University of California; Davis California

3. Graduate Group in Nutritional Biology -and- Department of Nutrition; University of California; Davis California

4. Arkansas Children's Nutrition Center -and- University of Arkansas for Medical Sciences; Department of Pediatrics; Little Rock Arkansas

Funder

XOMA, Inc.

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference40 articles.

1. Differential pathway coupling of the activated insulin receptor drives signaling selectivity by XMetA, an allosteric partial agonist antibody;Bedinger;J Pharmacol Exp Ther,2015

2. A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control;Bhaskar;Diabetes,2012

3. XMetA, an allosteric monoclonal antibody to the insulin receptor, improves glycaemic control in mice with diet-induced obesity;Bhaskar;Diabetes Obes Metab,2013

4. Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression;Bluher;J Biol Chem,2004

5. Mechanism of action of insulin in diabetic patients: A dose-related effect on glucose production and utilisation;Brown;Br Med J,1978

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2. Anti-Insulin Receptor Antibodies Improve Hyperglycemia in a Mouse Model of Human Insulin Receptoropathy;Diabetes;2020-08-17

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5. Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody;Molecular Metabolism;2018-04

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