Defining the optimal dose of rifapentine for pulmonary tuberculosis: Exposure-response relations from two phase II clinical trials

Author:

Savic RM1,Weiner M23,MacKenzie WR4,Engle M3,Whitworth WC4,Johnson JL56,Nsubuga P6,Nahid P78,Nguyen NV8,Peloquin CA9,Dooley KE10,Dorman SE10,

Affiliation:

1. University of California San Francisco School of Pharmacy; San Francisco California USA

2. Veterans Administration Medical Center; San Antonio Texas USA

3. University of Texas Health Science Center; San Antonio Texas USA

4. Centers for Disease Control and Prevention; Atlanta Georgia USA

5. Case Western Reserve University School of Medicine and University Hospitals Case Medical Center; Cleveland Ohio USA

6. Uganda-Case Western Reserve University Research Collaboration; Kampala Uganda

7. University of California San Francisco School of Medicine; San Francisco California USA

8. National Tuberculosis Program; Hanoi Vietnam

9. College of Pharmacy and Emerging Pathogens Institute; University of Florida; Gainesville Florida USA

10. Johns Hopkins University School of Medicine; Baltimore Maryland USA

Funder

United States Division of Tuberculosis Elimination

National Center for HIV/AIDS

Viral Hepatitis

STD

TB Prevention

Centers for Disease Control and Prevention

Veterans Administration

National Center for Advancing Translational Sciences

National Institutes of Health

Clinical and Translational Science Award

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference26 articles.

1. Centers for Disease Control and Prevention Web site Tuberculosis: data and statistics http://www.cdc.gov/tb/statistics/default.htm 2013

2. Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model;Rosenthal;PLoS Med.,2007

3. Substitution of rifapentine for rifampin during intensive phase treatment of pulmonary tuberculosis: study 29 of the tuberculosis trials consortium;Dorman;J. Infect. Dis.,2012

4. Daily rifapentine for treatment of pulmonary tuberculosis. A randomized, dose-ranging trial;Dorman;Am. J. Respir. Crit. Care Med.,2015

5. Assessment of new sterilizing drugs for treating pulmonary tuberculosis by culture at 2 months;Mitchison;Am. Rev. Respir. Dis.,1993

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