Exploring the therapeutic potential of naturally occurring piceatannol in non‐communicable diseases

Author:

Gandhi Himanshu1,Mahant Shikha1,Sharma Abhishek Kumar1,Kumar Deepak1,Dua Kamal2,Chellappan Dinesh Kumar3ORCID,Singh Sachin Kumar4ORCID,Gupta Gaurav56ORCID,Aljabali Alaa A. A.7,Tambuwala Murtaza M.8,Kapoor Deepak N.1ORCID

Affiliation:

1. School of Pharmaceutical Sciences Shoolini University of Biotechnology and Management Sciences Solan Himachal Pradesh India

2. Discipline of Pharmacy Graduate School of Health, University of Technology Sydney Ultimo New South Wales Australia

3. School of Pharmacy International Medical University Bukit Jalil Kaula Lumpur Malaysia

4. School of Pharmaceutical Sciences Lovely Professional University Phagwara Punjab India

5. School of Pharmacy Suresh Gyan Vihar University Jaipur India

6. Center for Transdisciplinary Research Saveetha Institute of Medical and Technical Sciences, Saveetha University Chennai India

7. Department of Pharmaceutics and Pharmaceutical Technology Yarmouk University Irbid Jordan

8. Lincoln Medical School, University of Lincoln, Brayford Pool Campus, Lincoln LN6 7TS England UK

Abstract

AbstractPiceatannol is a naturally occurring hydroxylated resveratrol analogue that can be found in a variety of fruits and vegetables. It has been documented to have a wide range of beneficial effects, including anti‐inflammatory, antioxidant, anti‐aging, anti‐allergic, antidiabetic, neuroprotective, cardioprotective, and chemopreventive properties. Piceatannol has significantly higher antioxidant activity than resveratrol. Piceatannol has been shown in preclinical studies to have the ability to inhibit or reduce the growth of cancers in various organs such as the brain, breast, lung, colon, cervical, liver, prostate, and skin. However, the bioavailability of Piceatannol is comparatively lower than resveratrol and other stilbenes. Several approaches have been reported in recent years to enhance its bioavailability and biological activity, and clinical trials are required to validate these findings. This review focuses on several aspects of natural stilbene Piceatannol, its chemistry, and its mechanism of action, and its promising therapeutic potential for the prevention and treatment of a wide variety of complex human diseases.

Publisher

Wiley

Subject

Clinical Biochemistry,Molecular Medicine,General Medicine,Biochemistry

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