Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating <scp>miRNA</scp> Profiles in Male <scp>C57BL</scp> / <scp>6J</scp> Mice-Reference-Cited by-同舟云学术

Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Male C57BL / 6J Mice

Published:2022-09-26 Issue:11 Volume:37 Page:2226-2243
ISSN:0884-0431
Container-title:Journal of Bone and Mineral Research
language:en
Short-container-title:J of Bone & Mineral Res

Author:

Carvalho Adriana Lelis¹,Brooks Daniel J²,Barlow Deborah³,Langlais Audrie L¹⁴,Morrill Breanna¹,Houseknecht Karen L⁴⁵,Bouxsein Mary L²^ORCID,Lian Jane B⁶⁷⁸,King Tamara⁴⁵⁹,Farina Nicholas H⁶⁷⁸,Motyl Katherine J¹⁴⁶¹⁰^ORCID

Affiliation:

1. Center for Molecular Medicine MaineHealth Institute for Research, MaineHealth Scarborough ME USA

2. Center for Advanced Orthopaedic Studies Beth Israel Deaconess Medical Center Boston MA USA

3. Department of Pharmacology University of New England Biddeford ME USA

4. Graduate School of Biomedical Sciences and Engineering University of Maine Orono ME USA

5. Department of Biomedical Sciences College of Osteopathic Medicine, University of New England Biddeford ME USA

6. Northern New England Clinical and Translational Research Network MaineHealth Portland ME USA

7. Department of Biochemistry and University of Vermont Cancer Center University of Vermont Burlington VT USA

8. Larner College of Medicine University of Vermont Cancer Center Burlington VT USA

9. Center for Excellence in the Neurosciences University of New England Biddeford ME USA

10. Tufts University School of Medicine Tufts University Boston MA USA

Funder

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Institute of General Medical Sciences

National Institutes of Health

Maine Medical Center Research Institute

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbmr.4690

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1. MECHANISMS OF ENDOCRINOLOGY: Endocrinology of opioids

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3. Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer

4. Opioid receptor agonists may favorably affect bone mechanical properties in rats with estrogen deficiency-induced osteoporosis

5. Expression of Opioid Receptors in Osteoblast-Like MG-63 Cells, and Effects of Different Opioid Agonists on Alkaline Phosphatase and Osteocalcin Secretion by These Cells

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