Affiliation:
1. Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China
2. Key Laboratory of Chemical Biology of Hebei Province College of Chemistry and Environmental Science Hebei University Baoding 071002 China
3. University of Chinese Academy of Sciences Beijing 100049 China
Abstract
AbstractSpleen is a large immune organ in the body. Splenic operations such as splenectomy and intrasplenic injection are of paramount importance for immunological research and splenic diseases. Fluorescence imaging can vastly simplify these operations, but a specific spleen‐targeting probe is still unavailable. Herein, the first specific spleen‐accumulated fluorescent probe, VIX‐S is reported, which fluoresces at 1064 nm and is highly stable. Systematic studies reveal the superior targeting and imaging performance of VIX‐S for the spleen in both nude and haired mice. In vivo imaging indicates that the probe can image the morphology of spleen with a signal‐background ratio of at least two‐fold higher than that of the liver. Moreover, the application of VIX‐S in imaging‐guided splenic operation, including splenic injury and intrasplenic injection, is demonstrated, which may provide a practice tool for spleen research in the animal model.
Funder
National Natural Science Foundation of China
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
2 articles.
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