Affiliation:
1. School of Materials Science and Engineering GuangDong Engineering Technology Research Center of Metallic Materials Surface Functionalization National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology Medical Devices Research and Testing Center South China University of Technology Guangzhou 510641 Guangzhou 510006 China
Abstract
AbstractHydrogels are well‐suited for biomedical applications due to their numerous advantages, such as excellent bioactivity, versatile physical and chemical properties, and effective drug delivery capabilities. Recently, hydrogel coatings have developed to functionalize bone implants which are biologically inert and cannot withstand the complex bone tissue repair microenvironment. These coatings have shown promise in addressing unique and pressing medical needs. This review begins with the major functionalized performance and interfacial bonding strategy of hydrogel coatings, with a focus on the novel external field response properties of the hydrogel. Recent advances in the fabrication strategies of hydrogel coatings and their use in the treatment of pathologic bone regeneration are highlighted. Finally, challenges and emerging trends in the evolution and application of physiological environment‐responsive and external electric field‐responsive hydrogel coatings for bone implants are discussed.
Funder
National Basic Research Program of China
National Natural Science Foundation of China
China Postdoctoral Science Foundation