Affiliation:
1. Biomedical Engineering Department McGill University Montreal QC H3A 0G4 Canada
2. McGill Genome Centre McGill University Montreal QC H3A 0G4 Canada
3. Department of Biomedical Engineering The University of Akron Akron OH 44325 USA
4. Institute of Biomaterials and Biomedical Engineering University of Toronto Toronto ON M1C 1A4 Canada
5. Institute of Biomedical Engineering Department of Pharmacology and Physiology Faculty of Medicine University of Montreal Montreal QC H3C 3J7 Canada
6. Research Center Centre Hospitalier Universitaire Sainte‐Justine Montreal QC H3T 1C5 Canada
7. Montreal TransMedTech Institute Montreal QC H3C 3A7 Canada
Abstract
AbstractArtificial organs and organs‐on‐a‐chip (OoC) are of great clinical and scientific interest and have recently been made by additive manufacturing, but depend on, and benefit from, biocompatible, biodegradable, and soft materials. Poly(octamethylene maleate (anhydride) citrate (POMaC) meets these criteria and has gained popularity, and as in principle, it can be photocured and is amenable to vat‐photopolymerization (VP) 3D printing, but only low‐resolution structures have been produced so far. Here, a VP‐POMaC ink is introduced and 3D printing of 80 µm positive features and complex 3D structures is demonstrated using low‐cost (≈US$300) liquid‐crystal display (LCD) printers. The ink includes POMaC, a diluent and porogen additive to reduce viscosity within the range of VP, and a crosslinker to speed up reaction kinetics. The mechanical properties of the cured ink are tuned to match the elastic moduli of different tissues simply by varying the porogen concentration. The biocompatibility is assessed by cell culture which yielded 80% viability and the potential for tissue engineering illustrated with a 3D‐printed gyroid seeded with cells. VP‐POMaC and low‐cost LCD printers make the additive manufacturing of high resolution, elastomeric, and biodegradable constructs widely accessible, paving the way for a myriad of applications in tissue engineering and 3D cell culture as demonstrated here, and possibly in OoC, implants, wearables, and soft robotics.
Funder
Fonds de recherche du Québec – Nature et technologies
Natural Sciences and Engineering Research Council of Canada
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献