Advancements in Skin‐Mediated Drug Delivery: Mechanisms, Techniques, and Applications

Author:

Lee Dong Ha12,Lim Sunyoung13,Kwak Sung Soo1,Kim Joohee1ORCID

Affiliation:

1. Center for Bionics of Biomedical Research Division Korea Institute of Science and Technology Seoul 02792 Republic of Korea

2. Department of Materials Science and Engineering Yonsei University Seoul 03722 Republic of Korea

3. School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea

Abstract

AbstractSkin‐mediated drug delivery methods currently are receiving significant attention as a promising approach for the enhanced delivery of drugs through the skin. Skin‐mediated drug delivery offers the potential to overcome the limitations of traditional drug delivery methods, including oral administration and intravenous injection. The challenges associated with drug permeation through layers of skin, which act as a major barrier, are explored, and strategies to overcome these limitations are discussed in detail. This review categorizes skin‐mediated drug delivery methods based on the means of increasing drug permeation, and it provides a comprehensive overview of the mechanisms and techniques associated with these methods. In addition, recent advancements in the application of skin‐mediated drug delivery are presented. The review also outlines the limitations of ongoing research and suggests future perspectives of studies regarding the skin‐mediated delivery of drugs.

Funder

National Research Foundation

Korea Institute of Science and Technology

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

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