Affiliation:
1. School of Basic Medical Sciences Shanxi Medical University Taiyuan 030001 P. R. China
2. The Radiology Department of First Hospital of Shanxi Medical University Taiyuan 030001 China
3. Third Hospital of Shanxi Medical University Shanxi Bethune Hospital Shanxi Academy of Medical Sciences Taiyuan 030032 P. R. China
Abstract
AbstractThe synergistic strategy of nanozyme‐based catalytic therapy and photothermal therapy holds great potential for combating bacterial infection. However, challenges such as single and limited enzyme catalytic property, unfavorable catalytic environment, ineffective interaction between nanozymes and bacteria, unsafe laser irradiation ranges, and failed trauma fluid management impede their antibacterial capability and wound healing speed. Herein, for the first time, a PNMn hydrogel is fabricated with multi‐enzyme activities and excellent near‐infrared (NIR)‐II photothermal performance for self‐enhanced NIR‐II photothermal‐catalytic capabilities to efficiently eradicate bacteria. This hydrogel triggers parallel and cascade reactions to generate •OH, •O2−, and 1O2 radicals from H2O2 and O2 without external energy input. Notably, it provides a suitable catalytic environment while capturing bacteria (≈30.1% of Escherichia coli and ≈29.3% of Staphylococcus aureus) to reinforce antibacterial activity. Furthermore, the PNMn hydrogel expedites skin wound healing by managing excess fluid (swelling rate up to ≈7299%). The PNMn hydrogel possesses remarkable stretching, elasticity, toughness, and adhesive characteristics under any shape of the wound, thus making it suitable for wound dressing. Therefore, the PNMn hydrogel has great potential to be employed as a next‐generation wound dressing in the clinical context, providing a non‐antibiotic strategy to improve the antibacterial performance and promote wound healing.
Funder
National Natural Science Foundation of China
Shanxi Scholarship Council of China
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials