Mass Spectrometry Imaging of Organoids to Improve Preclinical Research

Author:

Zivko Cristina12,Hahm Tae‐Hun3,Tressler Cay3,Brown Dalton3,Glunde Kristine345,Mahairaki Vasiliki12ORCID

Affiliation:

1. Department of Genetic Medicine Johns Hopkins School of Medicine Baltimore MD 21205 USA

2. The Richman Family Precision Medicine Center of Excellence in Alzheimer's Disease Johns Hopkins School of Medicine Baltimore MD 21205 USA

3. Russell H. Morgan Department of Radiology and Radiological Science Division of Cancer Imaging Research Johns Hopkins School of Medicine Baltimore MD 21205 USA

4. The Sidney Kimmel Comprehensive Cancer Center The Johns Hopkins University School of Medicine Baltimore MD 21231 USA

5. Department of Biological Chemistry The Johns Hopkins University School of Medicine Baltimore MD 21205 USA

Abstract

AbstractPreclinical models are essential research tools before novel therapeutic or diagnostic methods can be applied to humans. These range from in vitro cell monocultures to vastly more complex animal models, but clinical translation to humans often fails to deliver significant results. Three‐dimensional (3D) organoid systems are being increasingly studied to establish physiologically relevant in vitro platforms in a trade‐off between the complexity of the research question and the complexity of practical experimental setups. The sensitivity and precision of analytical tools are yet another limiting factors in what can be investigated, and mass spectrometry (MS) is one of the most powerful analytical techniques available to the scientific community. Its innovative use to spatially resolve biological samples has opened many research avenues in the field of MS imaging (MSI). Here, this work aims to explore the current scientific landscape in the application of MSI on organoids, with an emphasis on their combined potential to facilitate and improve preclinical studies.

Funder

National Institutes of Health

Publisher

Wiley

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