Affiliation:
1. The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN) Department of Health Technology Technical University of Denmark Ørsted Plads Kgs. Lyngby 2800 Denmark
2. Department of Health Technology Technical University of Denmark Kgs. Lyngby 2800 Denmark
3. College of Marine Life Sciences Ocean University of China No.5 Yushan Road Qingdao 266003 China
Abstract
AbstractBacterial biofilms are linked to several diseases and cause resistant and chronic infections in immune‐compromised patients. Nanomotors comprise a new field of research showing a great promise within biomedicine but pose challenges in terms of biocompatibility. Nanomotors propelled by thermophoresis could overcome this challenge, as they leave no waste product during propulsion. In this study, mesoporous‐silica nanoparticles are coated with a thin layer of gold to make nanomotors, which can be driven by near‐infrared (NIR) light irradiation. The prepared mesoporous SiO2‐Au nanomotors exhibit efficient self‐propulsion when exposed to NIR irradiation, they penetrate deep through a biofilm matrix, and disperse the biofilm in situ due to the photothermal effect on the Au part of the nanomotors. The velocities of such nanomotors are investigated at different wavelengths and laser powers. Furthermore, the study examines the ability of these nanomotors to eradicate Pseudomonas aeruginosa (P. aeruginosa) biofilm under NIR light irradiation. The conducted study shows that the nanomotor's velocity increases with increasing laser power. The mesoporous SiO2/Au nanomotors show excellent capabilities to eradicate P. aeruginosa biofilms even under short (30 s–3 min) irradiation time. This study shows great promise for overcoming the challenges related to bacterial biofilm eradication.
Funder
Danmarks Grundforskningsfond
Villum Fonden
Carlsbergfondet
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
10 articles.
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