Hybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy

Author:

Geng Hongya123ORCID,Lupton Emily J.4,Ma Yun1,Sun Rujie1,Grigsby Christopher L.2,Brachi Giulia1,Li Xiaorui3,Zhou Kun1,Stuckey Daniel J.4,Stevens Molly M.12ORCID

Affiliation:

1. Department of Materials Department of Bioengineering Institute of Biomedical Engineering Imperial College London London SW7 2AZ UK

2. Department of Medical Biochemistry and Biophysics Karolinska Institutet Stockholm Stockholm 171 11 Sweden

3. Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen 518055 China

4. UCL Centre for Advanced Biomedical Imaging Division of Medicine University College London London WC1E 6DD UK

Abstract

AbstractThe development of near‐infrared light responsive conductive polymers provides a useful theranostic platform for malignant tumors by maximizing spatial resolution with deep tissue penetration for diagnosis and photothermal therapy. Herein, the self‐assembly of ultrathin 2D polypyrrole nanosheets utilizing dopamine as a capping agent and a monolayer of octadecylamine as a template is demonstrated. The 2D polypyrrole‐polydopamine nanostructure has tunable size distribution which shows strong absorption in the first and second near‐infrared windows, enabling photoacoustic imaging and photothermal therapy. The hybrid double‐layer is demonstrated to increase Raman intensity for 3D Raman imaging (up to two orders of magnitude enhancement and spatial resolution up to 1 µm). The acidic environment drives reversible doping of polypyrrole, which can be detected by Raman spectroscopy. The combined properties of the nanosheets can substantially enhance performance in dual‐mode Raman and photoacoustic guided photothermal therapy, as shown by the 69% light to heat conversion efficiency and higher cytotoxicity against cancer spheroids. These pH‐responsive features highlight the potential of 2D conductive polymers for applications in accurate, highly efficient theranostics.

Funder

European Commission

British Heart Foundation

Wellcome Trust

Biotechnology and Biological Sciences Research Council

Karolinska Institutet

Medical Research Council

Rosetrees Trust

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

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