Affiliation:
1. Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing 211816 China
2. College of life and health Nanjing Polytechnic Institute Nanjing 210048 China
3. School of Physical Science and Information Technology Liaocheng University Liaocheng 252059 China
4. School of Chemistry & Materials Science Jiangsu Normal University Xuzhou 221116 China
Abstract
AbstractThe presence of a biofilm matrix barrier and hypoxic microenvironment within the biofilm significantly impedes the efficacy of photodynamic therapy for bacterial biofilm infections. Herein, a phototherapeutic nanoagent with type‐I photodynamic behavior and nitric oxide (NO) release performance is reported for overcoming biofilm‐associated infectious diseases. Sodium nitroprusside (SNP), a NO donor, is loaded onto amino‐modified mesoporous silica nanoparticles (MSN) to form MSN@SNP NPs. The resulting nanoparticles are further modified with a porphyrin‐based metal–organic framework (Ti‐TCPP MOF) to obtain MSN@MOF/SNP NPs (MMS NPs) for phototherapeutic applications. In the hypoxia biofilm microenvironment, the MMS NPs release NO to enhance the biofilm permeability and induce the generation of hydroxyl radical (•OH) and superoxide anion radical (O2•−) via Type‐I photodynamic pathway under laser irradiation. Subsequently, the biofilm‐associated infections are effectively eliminated through reactive oxygen species (ROS) and NO gas synergistic therapy. In addition, NO also stimulates collagen deposition and promotes angiogenesis in vivo. Therefore, the MMS NPs efficiently treat biofilm‐related infections, providing an alternative approach to combat biofilm‐associated infectious diseases.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
3 articles.
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