A Biomimicking and Multiarm Self‐Indicating Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombolysis Assessed in Microfluidic and In Vivo Models

Author:

Liu Kuan‐Ting1,Quiñones Edgar Daniel1,Liu Ming‐Hsin1,Lin Che‐Wei2,Chen Yan‐Ting3,Chiang Chia‐Che4,Wu Kevin Chia‐Wen15,Fan Yu‐Jui26,Chuang Er‐Yuan2347ORCID,Yu Jiashing1ORCID

Affiliation:

1. Department of Chemical Engineering National Taiwan University Taipei 10617 Taiwan

2. School of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan

3. Graduate Institute of Nanomedicine and Medical Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan

4. Graduate Institute of Biomedical Materials and Tissue Engineering College of Biomedical Engineering Taipei Medical University Taipei 11031 Taiwan

5. Institute of Biomedical Engineering & Nanomedicine National Health Research Institute Keyan Road, Zhunan Miaoli City 350 Taiwan

6. Center for Precision Health and Quantitative Sciences Taipei Medical University Hospital Taipei 11031 Taiwan

7. Cell Physiology and Molecular Image Research Center Taipei Medical University‐Wan Fang Hospital Taipei 11696 Taiwan

Abstract

AbstractThrombolytic and antithrombotic therapies are limited by short circulation time and the risk of off‐target hemorrhage. Integrating a thrombus‐homing strategy with photothermal therapy are proposed to address these limitations. Using glycol chitosan, polypyrrole, iron oxide and heparin, biomimicking GCPIH nanoparticles are developed for targeted thrombus delivery and thrombolysis. The nanoassembly achieves precise delivery of polypyrrole, exhibiting biocompatibility, selective accumulation at multiple thrombus sites, and enhanced thrombolysis through photothermal activation. To simulate targeted thrombolysis, a microfluidic model predicting thrombolysis dynamics in realistic pathological scenarios is designed. Human blood assessments validate the precise homing of GCPIH nanoparticles to activated thrombus microenvironments. Efficient near‐infrared phototherapeutic effects are demonstrated at thrombus lesions under physiological flow conditions ex vivo. The combined investigations provide compelling evidence supporting the potential of GCPIH nanoparticles for effective thrombus therapy. The microfluidic model also offers a platform for advanced thrombolytic nanomedicine development.

Funder

Ministry of Science and Technology

National Taiwan University

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

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