Affiliation:
1. CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China
2. University of Chinese Academy of Sciences Beijing 100049 China
Abstract
AbstractEpidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) in the treatment of non‐small cell lung cancer (NSCLC) still face challenges of acquired resistance and non‐negligible side effects. To overcome these limitations, a biodegradable coordination polymer using guanine deoxynucleotide and ferrous iron (dGNP) is developed for targeted delivery of EGFR‐TKIs. dGNPs can efficiently target nucleoside transporters in tumor cells that are regulated by fasting‐mimicking diet (FMD). Meanwhile, FMD can augment the therapeutic efficacy of EGFR‐TKIs by suppressing EGFR tyrosine kinase phosphorylation and related downstream pathways. In vivo results demonstrate that EGFR‐TKIs‐laden dGNPs combined with FMD treatment exhibit superior antitumor efficacy and reduced side effect. This study provides an innovative approach to enhance the therapeutic efficacy of EGFR‐TKIs through nucleotide nanocarrier and metabolic modulation.
Funder
National Natural Science Foundation of China
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials