Engineering Microorganisms for Cancer Immunotherapy

Author:

Liu Dingkang1ORCID,Yu Lichao1,Rong Haibo2,Liu Lubin3,Yin Jun1ORCID

Affiliation:

1. Jiangsu Key Laboratory of Druggability of Biopharmaceuticals State Key Laboratory of Natural Medicines School of Life Science and Technology China Pharmaceutical University No. 639 Longmian Avenue Nanjing 211198 China

2. Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital Nanjing 210009 China

3. Department of Obstetrics and Gynecology Women and Children's Hospital of Chongqing Medical University No. 120 Longshan Road Chongqing 401147 China

Abstract

AbstractCancer immunotherapy presents a promising approach to fight against cancer by utilizing the immune system. Recently, engineered microorganisms have emerged as a potential strategy in cancer immunotherapy. These microorganisms, including bacteria and viruses, can be designed and modified using synthetic biology and genetic engineering techniques to target cancer cells and modulate the immune system. This review delves into various microorganism‐based therapies for cancer immunotherapy, encompassing strategies for enhancing efficacy while ensuring safety and ethical considerations. The development of these therapies holds immense potential in offering innovative personalized treatments for cancer.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Fundamental Research Funds for the Central Universities

Publisher

Wiley

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