An Octopus‐Inspired Stimulus‐Responsive Structural Color Hydrogel for Uterus Cervical Canal Stent

Author:

Zhang Lihao1,Ren Lehao2,Chen Yufei1,Cao Yue1,Li Sunlong1,Lu Weipeng1,Jia Yaoyuan1,Li Yachun3,Liu Cihui1ORCID,Li Chen4,Dong Qian567

Affiliation:

1. Center for Future Optoelectronic Functional Materials School of Computer and Electronic Information/School of Artificial Intelligence Nanjing Normal University Nanjing 210023 China

2. Department of Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

3. Department of Pediatrics Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 201601 China

4. School of Electronic Science and Engineering Southeast University Nanjing 210096 China

5. Department of Obstetrics and Gynecology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200001 China

6. Shanghai Key Laboratory of Gynecologic Oncology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200001 China

7. State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200001 China

Abstract

AbstractSoft‐bodied aquatic organisms have exhibited remarkable capabilities in navigating and moving within liquid environments serving as a profound inspiration for the development of bionic robots with intricate movements. Traditional rigid components are being replaced by stimulus‐responsive soft materials such as hydrogels and shape memory polymers, leading to the creation of dynamically responsive soft robots. In this study, the development of a bionic robot inspired by the shape of an octopus and the adsorptive properties of its tentacles, specifically tailored for targeted stimulation and pH sensing in the cervix, are presented. This approach involves the design of a soft, water‐based Janus adhesive hydrogel patch that adheres to specific parts of the cervix and responds to pH changes through external stimuli. The hydrogel patch incorporates inverse opal microstructures mimicking the legs of an octopus, to facilitate efficient and stable locomotion, unidirectional transport of biofluids, and pH‐responsive behavior. This miniature bionic robot showcases controlled adhesion and precise unidirectional fluid transport highlighting its potential for targeted stimulus response and pH sensing in the uterine cervical tract. This breakthrough opens new avenues for medical applications within the expanding field of soft‐bodied robotics.

Funder

National Natural Science Foundation of China

Publisher

Wiley

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