Biomimetic Structure Hydrogel Loaded with Long‐Term Storage Platelet‐Rich Plasma in Diabetic Wound Repair

Author:

Ding Neng12ORCID,Fu Xinxin3,Gui Qixiang14,Wu Minjuan5,Niu Zhongpu3,Du Antong1,Liu Jinyue1,Wu Haimei3,Wang Yue467,Yue Xuezheng3,Zhu Lie1ORCID

Affiliation:

1. Department of Plastic and Reconstructive Surgery Second Affiliated Hospital of Naval Medical University (Shanghai Changzheng Hospital) 415 Fengyang Road Shanghai 200003 China

2. Department of Burns and Plastic Surgery The 74th Group Army Hospital of the PLA Army 468 Xingang Zhong Road Guangzhou 510315 China

3. School of Materials Science and Engineering University of Shanghai for Science and Technology 516 Jungong Road Shanghai 200082 China

4. Stem Cell and Regeneration Medicine Institute, Research Center of Translational Medicine Naval Medical University 800 Xiangyin Road Shanghai 200433 China

5. Department of Histology and Embryology, Basic Medicine College Naval Medical University 800 Xiangyin Road Shanghai 200433 China

6. Department of stem cell engneering Shanghai Institute of Stem Cell Research and Clinical Translation 551 Pudong Nan Road Shanghai 200120 China

7. Department of stem cell engneering Shanghai Key Laboratory of Cell Engineering 800 Xiangyin Road Shanghai 200433 China

Abstract

AbstractExploring the preparation of multifunctional hydrogels from a bionic perspective is an appealing strategy. Here, a multifunctional hydrogel dressing inspired by the characteristics of porous extracellular matrix produced during Acomys wound healing is prepared. These dressings are printed by digital light processing printing of hydrogels composed of gelatin methacrylate, hyaluronic acid methacrylate, and pretreated platelet‐rich plasma (PRP) to shape out triply periodic minimal surface structures, which are freeze‐dried for long‐term storage. These dressings mimic the porous extracellular matrix of Acomys, while the freeze‐drying technique effectively extends the storage duration of PRP viability. Through in vivo and in vitro experiments, the biomimetic dressings developed in this study modulate cell behavior and facilitate wound healing. Consequently, this research offers a novel approach for the advancement of regenerative wound dressings.

Funder

Shanghai Municipal Education Commission

Science and Technology Commission of Shanghai Municipality

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

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