Mechanical‐Enhanced and Durable Zwitterionic Hydrogel Coating for Inhibiting Coagulation and Reducing Bacterial Infection

Author:

Yan Zhuojun1,Yao Mengmeng12,Zhao Zhongming1,Yang Qi1,Liu Rui1,Liu Baijun1,Wang Xueyu1,Chen Liming3,Zhang Hong14,Wei Yuping5,Yao Fanglian14ORCID,Li Junjie14ORCID

Affiliation:

1. School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

2. Biomedical Engineering Cockrell School of Engineering University of Texas at Austin Austin TX 78712 USA

3. Department of Anorectal Surgery Tianjin Hospital Tianjin University Tianjin 300211 China

4. Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education) Tianjin University Tianjin 300350 China

5. Department of Chemistry School of Science Tianjin University Tianjin 300350 China

Abstract

AbstractBlood‐contact medical devices are indispensable for clinical interventions, yet their susceptibility to thrombosis and bacterial infections poses substantial risks to treatment efficacy and patient well‐being. This study introduces a polysulfobetaine/alginate‐CuII (SAC) zwitterionic hydrogel coating on polyurethane (PU) surfaces. This approach retains the superhydrophilic and antifouling nature of pSBMA while conferring the antibacterial effects of copper ions. Meanwhile, the copper alginate network intertwines with the polysulfobetaine (pSBMA) network, enhancing its mechanical properties and overcoming inherent weaknesses, thereby improving coating durability. Compared to the substrate, the SAC hydrogel coating significantly reduces thrombus adhesion mass by approximately 81.5% during extracorporeal blood circulation and effectively prevents bacterial biofilm formation even in a high‐concentration bacterial milieu over 30 days. Moreover, the results from an isolated blood circulation model in New Zealand white rabbits affirm the impressive anticoagulant efficacy of the SAC hydrogel coating. The findings suggest that this hydrogel coating and its application method hold promise as a solution for blood‐contact material surface modification to address thrombosis and bacterial biofilm formation simultaneously.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Tianjin Municipality

Social Trends Institute

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3