Awakening Allies for Breaking Microenvironment Barriers: NIR‐II Guided Orthogonal Activation of Tumor‐Infiltrating Mast Cells for Efficient Nano‐Drug Delivery

Author:

Wang Qingyuan1,Yang Haiyan1,Liu Yuan2,Zhou Zhaoxi2,Zhang Xu1,Sang Mingyi1,Xu Feng1,Song Lebin3,Xia Tiansong1,Zhang Yue2,Wei Jifu45,Zhang Xiaobo2ORCID,Ding Qiang1

Affiliation:

1. Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road Nanjing 210029 China

2. State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 China

3. Department of Dermatology The First Affiliated Hospital of Nanjing Medical University 300 Guangzhou Road Nanjing 210029 China

4. Department of Pharmacy Jiangsu Cancer Hospital The Affiliated Cancer Hospital of Nanjing Medical University Jiangsu Institute of Cancer Research Nanjing 210009 China

5. Department of Clinical Pharmacy School of Pharmacy Nanjing Medical University Nanjing 211103 China

Abstract

AbstractMast cells (MCs), powerful immune cells that heavily infiltrate cancer cells, play a crucial role in tumor formation. Activated MCs can release histamine and a family of proteases through degranulation effects, concurrently achieving endothelial junction weakening and stromal degradation of the tumor microenvironment, thereby clearing the obstacles for nano‐drug infiltration. To achieve precise activation of tumor‐infiltrating MCs, orthogonally excited rare earth nanoparticles (ORENP), with two channels, are introduced for the controllable stimulating drugs release wrapped in “photocut tape”. The ORENP can emit near‐infrared II (NIR‐II) for image tracing for tumor localization in Channel 1 (808/NIR‐II) and allows energy upconversion to emit ultraviolet (UV) light for releasing drugs for MCs stimulation in Channel 2 (980/UV). Finally, the combined use of chemical and cellular tools enables clinical nano‐drugs to achieve a significant increase in tumor infiltration, thereby enhancing the efficacy of nano‐chemotherapy.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3