Affiliation:
1. National and Regional Engineering Laboratory of Tissue Engineering Key Lab for Biomechanics and Tissue Engineering of Chongqing Department of Anatomy Army Medical University (Third Military Medical University) Chongqing 400038 China
2. State Key Laboratory of Primate Biomedical Research Institute of Primate Translational Medicine Kunming University of Science and Technology Kunming 650500 China
3. State Key Laboratory of Trauma Burn and Combined Injury Chongqing 400038 China
Abstract
AbstractElectrical stimulation is an effective strategy for facilitating wound healing. However, it is hindered by unwieldy electrical systems. In this study, a light‐powered dressing based on long‐lived photoacid generator (PAG)‐doped polyaniline composites is used, which can generate a photocurrent under visible light irradiation to interact with the endogenous electric field and facilitate skin growth. Light‐controlled proton binding and dissociation result in oxidation and reduction of the polyaniline backbone, inducing charge transfer to generate a photocurrent. Due to the rapid intramolecular photoreaction of PAG, a long‐lived proton‐induced localized acidic environment is formed, which protects the wound from microbial infection. In summary, a simple and effective therapeutic strategy is introduced for light‐powered and biocompatible wound dressings that show great potential for wound treatment.
Funder
National Science Fund for Distinguished Young Scholars
National Natural Science Foundation of China
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
3 articles.
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