Transformative Materials for Interfacial Drug Delivery-Reference-Cited by-同舟云学术

Transformative Materials for Interfacial Drug Delivery

Published:2023-06-06 Issue:20 Volume:12 Page:
ISSN:2192-2640
Container-title:Advanced Healthcare Materials
language:en
Short-container-title:Adv Healthcare Materials

Author:

Desai Prachi¹^ORCID,Dasgupta Anshuman¹,Sofias Alexandros Marios¹²^ORCID,Peña Quim¹^ORCID,Göstl Robert³^ORCID,Slabu Ioana⁴^ORCID,Schwaneberg Ulrich⁵^ORCID,Stiehl Thomas²⁶^ORCID,Wagner Wolfgang²⁷⁸^ORCID,Jockenhövel Stefan⁹^ORCID,Stingl Julia¹⁰^ORCID,Kramann Rafael¹¹¹²^ORCID,Trautwein Christian²¹³,Brümmendorf Tim H.²¹⁴,Kiessling Fabian¹²⁷^ORCID,Herrmann Andreas³¹⁵^ORCID,Lammers Twan¹²⁷^ORCID

Affiliation:

1. Institute for Experimental Molecular Imaging RWTH Aachen University Hospital 52074 Aachen Germany

2. Center for Integrated Oncology Aachen Bonn Cologne Düsseldorf (CIO^ABCD) 52074 Aachen Germany

3. DWI – Leibniz Institute for Interactive Materials 52074 Aachen Germany

4. Institute of Applied Medical Engineering Helmholtz Institute Medical Faculty RWTH Aachen University 52074 Aachen Germany

5. Institute of Biotechnology RWTH Aachen University 52074 Aachen Germany

6. Institute for Computational Biomedicine – Disease Modeling RWTH Aachen University 52074 Aachen Germany

7. Helmholtz‐Institute for Biomedical Engineering Medical Faculty of RWTH Aachen University 52074 Aachen Germany

8. Institute for Stem Cell Biology University Hospital of RWTH Aachen 52074 Aachen Germany

9. Department of Biohybrid & Medical Textiles (BioTex) AME – Institute of Applied Medical Engineering Helmholtz Institute Aachen RWTH Aachen University 52074 Aachen Germany

10. Institute of Clinical Pharmacology University Hospital RWTH Aachen 52074 Aachen Germany

11. Division of Nephrology and Clinical Immunology RWTH Aachen University 52074 Aachen Germany

12. Institute of Experimental Medicine and Systems Biology RWTH Aachen University 52074 Aachen Germany

13. Department of Medicine III (Gastroenterology Metabolic diseases and Intensive Care) University Hospital RWTH Aachen 52074 Aachen Germany

14. Department of Hematology Oncology Hemostaseology and Stem Cell Transplantation RWTH Aachen University Medical School 52074 Aachen Germany

15. Institute of Technical and Macromolecular Chemistry RWTH Aachen University Worringerweg 1 52074 Aachen Germany

Abstract

AbstractDrug delivery systems (DDS) are designed to temporally and spatially control drug availability and activity. They assist in improving the balance between on‐target therapeutic efficacy and off‐target toxic side effects. DDS aid in overcoming biological barriers encountered by drug molecules upon applying them via various routes of administration. They are furthermore increasingly explored for modulating the interface between implanted (bio)medical materials and host tissue. Herein, an overview of the biological barriers and host‐material interfaces encountered by DDS upon oral, intravenous, and local administration is provided, and material engineering advances at different time and space scales to exemplify how current and future DDS can contribute to improved disease treatment are highlighted.

Funder

Bundesministerium für Bildung und Forschung

European Research Council

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/adhm.202301062

Reference135 articles.

1. Drug Delivery Systems: Entering the Mainstream