A Horn Peptide‐Thermoresponsive Hydrogel for Angiogenesis and Bone Regeneration

Author:

Xue Nannan123ORCID,Liu Pei23,Zhao Wenjian1,Zhou Ziyi1,Zhang Lixiang1,Huang Rizhong1,Liu Rui23,Fathi Ali45,Duan Jin‐Ao23,Chen Jun12,Wang Yiwei123ORCID

Affiliation:

1. Jiangsu Provincial Engineering Research Center of TCM External Medication Development and Application Nanjing University of Chinese Medicine Nanjing 210023 P. R. China

2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese Medicine Nanjing 210023 P. R. China

3. International Cooperative Joint Laboratory of Animal‐Derived Chinese Medicine and Functional Peptides Nanjing 210023 P. R. China

4. School of Chemical and Biomolecular Engineering University of Sydney Sydney NSW 2006 Australia

5. Tetratherix Technology Pty Ltd Sydney NSW 2000 Australia

Abstract

AbstractThe management of critical‐sized bone defects presents a formidable clinical challenge, especially given the increasing incidence of bone diseases in the aging population. Consequently, there is an increased demand for minimally invasive bone repair materials that can effectively address this challenge, particularly in outpatient settings. In this study, the goal is to develop an injectable and biodegradable biomaterial that adheres to and fills bone‐defect sites to support bone regeneration. The osteogenic and angiogenic activities of animal horn peptides are investigated by incorporating them into biologically active moieties, in combination with a novel thermosensitive hydrogel. The resulting thermosensitive hydrogel exhibited essential biological functionalities, allowing precise modulation of its physical and chemical properties. Notably, the hydrogel incorporating the horn peptide rapidly filled the bone defect site, promoting both angiogenesis and bone induction. Consequently, this approach significantly accelerates new bone regeneration. In summary, the findings of this study present a promising, minimally invasive solution for addressing critical‐sized bone defects.

Funder

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization

Publisher

Wiley

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