Affiliation:
1. Hubei Provincial Key Laboratory of Green Materials for Light Industry Hubei University of Technology Wuhan 430068 China
2. Bioengineering Department College of Engineering University of Massachusetts Dartmouth North Dartmouth Bristol County MA 02747‐2300 USA
3. Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060 China
4. Department of Chemistry University College London 20 Gordon St London WC1H 0AJ UK
5. New Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base Hubei University of Technology Wuhan 430068 China
6. Hubei Longzhong Laboratory Xiangyang 441000 China
Abstract
AbstractHydrogels usually are fabricated by using monomers or preexisting polymers in precursor solutions. Here, a polyelectrolyte complex biohydrogel (Bio‐PEC hydrogel) made from a precursor dough, by kneading, annealing, and crosslinking the dough of two oppositely charged polysaccharides, cationic chitosan quaternary ammonium salt (HACC) and anionic sodium hyaluronate (HA), photoinitiator (α‐ketoglutaric acid), crosslinker glycidyl methacrylate (GMA), and water of very small quantity is reported. Controlled kneading and annealing homogenized the dough with respect to transforming randomly distributed, individual polymer chains into tightly wound double‐stranded structures, which, upon UV irradiation, covalently sparsely crosslinked into a highly entangled network and subsequently, upon fully swollen in water, results in Bio‐PEC hydrogel, HACC/HA, exhibiting near‐perfect elasticity, high tensile strength, and high swelling resistance. Via the same kneading and annealing, tetracarboxyphenylporphyrin iron (Fe‐TCPP) metal nanoclusters are incorporated into HACC/HA to obtain photocatalytic, antibacterial, and biocompatible Bio‐PEC hydrogel composite, Fe‐TCPP@HACC/HA. Using SD rat models, the efficacy of Fe‐TCPP@HACC/HA in inhibiting Escherichia coli (E. coli) growth in vitro and the ability to promote wound healing and scar‐free skin regeneration in vivo, or its high potential as a wound dressing material for biomedical applications are demonstrated.
Funder
National Natural Science Foundation of China
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials