Affiliation:
1. Institute of Otolaryngology Head and neck surgery Guangzhou Red Cross Hospital of Jinan University Guangzhou 510282 P. R. China
2. School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 P. R. China
3. Department of Dermatology The Third Hospital of Hebei Medical University Shijiazhuang Hebei 050051 P. R. China
4. Institute of Biomedical Health Technology and Engineering Shenzhen Bay Laboratory Shenzhen 518132 P. R. China
5. Institute for Engineering Medicine Kunming Medical University Kunming 650500 P. R. China
Abstract
AbstractEmerging infectious diseases like coronavirus pneumonia (COVID‐19) present significant challenges to global health, extensively affecting both human society and the economy. Extracellular vesicles (EVs) have demonstrated remarkable potential as crucial biomedical tools for COVID‐19 diagnosis and treatment. However, due to limitations in the performance and titer of natural vesicles, their clinical use remains limited. Nonetheless, EV‐inspired strategies are gaining increasing attention. Notably, biomimetic vesicles, inspired by EVs, possess specific receptors that can act as “Trojan horses,” preventing the virus from infecting host cells. Genetic engineering can enhance these vesicles by enabling them to carry more receptors, significantly increasing their specificity for absorbing the novel coronavirus. Additionally, biomimetic vesicles inherit numerous cytokine receptors from parent cells, allowing them to effectively mitigate the “cytokine storm” by adsorbing pro‐inflammatory cytokines. Overall, this EV‐inspired strategy offers new avenues for the treatment of emerging infectious diseases. Herein, this review systematically summarizes the current applications of EV‐inspired strategies in the diagnosis and treatment of COVID‐19. The current status and challenges associated with the clinical implementation of EV‐inspired strategies are also discussed. The goal of this review is to provide new insights into the design of EV‐inspired strategies and expand their application in combating emerging infectious diseases.
Funder
National Natural Science Foundation of China
Cited by
2 articles.
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