Affiliation:
1. Department of Orthopaedics Center for Orthopaedic Science and Translational Medicine Shanghai Tenth People's Hospital School of Medicine Tongji University 301 Yanchang Road Shanghai 200072 P. R. China
2. Department of Orthopedics Second Affiliated Hospital of Naval Medical University 415 Fengyang Road Shanghai 200003 P. R. China
3. Baidu, Inc. 701 Naxian Road Shanghai 201210 P. R. China
4. Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Stomatological Hospital and School of Stomatology Fudan University Shanghai 200001 P. R. China
Abstract
AbstractBandages for daily wounds are the most common medical supplies, but there are still ingrained defects in their appearance, comfort, functions, as well as environmental pollution. Here, novel bandages based on bacterial cellulose (BC) membrane for wound monitoring and advanced wound management are developed. The BC membrane is combined with silver nanowires (AgNWs) by using vacuum filtration method to achieve transparent, ultrathin (≈7 µm), breathable (389.98–547.79 g m−2 d−1), and sandwich‐structured BC/AgNWs bandages with superior mechanical properties (108.45–202.35 MPa), antibacterial activities against Escherichia coli and Staphylococcus aureus, biocompatibility, and conductivity (9.8 × 103–2.0 × 105 S m−1). Significantly, the BC/AgNWs bandage is used in the electrical stimulation (direct current, 600 microamperes for 1 h every other day) treatment of full‐thickness skin defect in rats, which obviously promotes wound healing by increasing the secretion of vascular endothelial growth factor (VEGF). The BC bandage is used for monitoring wounds and achieve a high accuracy of 94.7% in classifying wound healing stages of hemostasis, inflammation, proliferation, and remodeling, by using a convolutional neural network. The outcomes of this study not only provide two BC‐based bandages as multifunctional wound management, but also demonstrate a new strategy for the development of the next generation of smart bandage.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Science and Technology Commission of Shanghai Municipality
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials