Affiliation:
1. Institute for Orthopedic Research and Biomechanics Ulm University Medical Center Helmholtzstraße 14 D‐89081 Ulm Germany
2. Department for Functional Materials in Medicine and Dentistry University Hospital Würzburg Pleicherwall 2 D‐97070 Würzburg Germany
Abstract
AbstractIn clinical practice, hydroxyapatite (HA) cements for bone defect treatment are frequently prepared by mixing a powder component and a liquid component shortly before implantation in the operation theater, which is time‐consuming and error‐prone. In addition, HA cements are only slightly resorbed, that is, cement residues can still be found in the bone years after implantation. Here, these challenges are addressed by a prefabricated magnesium phosphate cement paste based on glycerol, which is ready‐to‐use and can be directly applied during surgery. By using a trimodal particle size distribution (PSD), the paste is readily injectable and exhibits a compressive strength of 9–14 MPa after setting. Struvite (MgNH4PO4·6H2O), dittmarite (MgNH4PO4·H2O), farringtonite (Mg3(PO4)2), and newberyite (MgHPO4·3H2O) are the mineral phases present in the set cement. The paste developed here features a promising degradation of 37% after four months in an ovine implantation model, with 25% of the implant area being newly formed bone. It is concluded that the novel prefabricated paste improves application during surgery, has a suitable degradation rate, and supports bone regeneration.
Funder
Deutsche Forschungsgemeinschaft
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
1 articles.
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