An Ultraswelling Microneedle Device for Facile and Efficient Drug Loading and Transdermal Delivery

Author:

Li Zhiming1,Zhao Puxuan12,Ling Zhixin1,Zheng Yanting13,Qu Fengli1,Chang Hao1ORCID

Affiliation:

1. Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences Hangzhou Zhejiang 310022 China

2. College of Materials Science and Engineering Zhejiang University of Technology Hangzhou Zhejiang 310014 China

3. College of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou Zhejiang 310014 China

Abstract

AbstractThe advancement and extensive demand for transdermal therapies can benefit from a safe, and efficient and user‐friendly transdermal technology with broad applicability in delivering various hydrophilic drugs. Here the design and proof of concept applications of an ultraswelling microneedle device that enables the facile and efficient loading and transdermal delivery of hydrophilic drugs with different molecular weights is reported. The device consists of a super‐hydrophilic hydrogel microneedle array and a resin base substrate. Using a special micromolding technique that involves hydrated crosslinking and cryogenic‐demolding, the microneedle part displays a rapid swelling ratio of ≈3800%, enabling the loading of drugs up to 500 kDa in molecular weight. The drug loading process using the device just involves incubating the microneedle part in a drug solution for 1 min, followed by 15 min of drying. The microneedles can easily penetrate the skin under press and detach from the base substrate under shear, thereby releasing the payload. Administration of desired therapeutic agents using the device outperformed conventional administration methods in mitigating psoriasis and eliciting immunity. This biocompatible device, capable of withstanding ethylene oxide sterilization, can enhance the efficacy and accessibility of transdermal therapies in research institutes, hospitals, and even home settings

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

Subject

Pharmaceutical Science,Biomedical Engineering,Biomaterials

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