Affiliation:
1. Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Provincial People's Hospital, and School of Life Science and Technology University of Electronic Science and Technology of China Chengdu 610054 P. R. China
2. TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese Medicine No. 39 Shi‐er‐qiao Road Chengdu 610072 P. R. China
3. Chongqing Engineering Laboratory of Nano/Micro Biomedical Detection Technology Chongqing University of Science and Technology Chongqing 401331 P. R. China
Abstract
AbstractPhotothermal therapy (PTT) is considered a promising treatment for tumors; however, its efficacy is restricted by heat shock proteins (HSPs). Herein, a stimuli‐responsive theranostic nanoplatform (M/D@P/E‐P) is designed for synergistic gas therapy and PTT. This nanoplatform is fabricated by a load of manganese carbonyl (MnCO, CO donor) in dendritic mesoporous silicon (DMS), followed by the coating with polydopamine (PDA) and loading of epigallocatechin gallate (EGCG, HSP90 inhibitor). Upon near‐infrared (NIR) irradiation, the photothermal effect of PDA can kill tumor cells and allow for the controlled drug release of MnCO and EGCG. Moreover, the acidity and H2O2‐rich tumor microenvironment enable the decomposition of the released MnCO, accompanied by the production of CO. CO‐initiated gas therapy can realize to disrupt the mitochondrial function, which will accelerate cell apoptosis and down‐regulate HSP90 expression by decreasing intracellular ATP. The combination of EGCG and MnCO can significantly minimize the thermo‐resistance of tumors and improve PTT sensitivity. In addition, the released Mn2+ enables T1‐weighted magnetic imaging of tumors. The therapeutic efficacy of the nanoplatform is methodically appraised and validated both in vitro and in vivo. Taken together, this study affords a prime paradigm for applying this strategy for enhanced PTT via mitochondrial dysfunction.
Funder
National Natural Science Foundation of China
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
10 articles.
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