Affiliation:
1. School of Materials Science and Engineering Zhengzhou Key Laboratory of Flexible Electronic Materials and Thin‐Film Technologies Henan Innovation Center for Functional Polymer Membrane Materials Henan Key Laboratory of Advanced Nylon Materials and Application Zhengzhou University Zhengzhou 450001 China
2. Sinopec Oilfield Equipment Corporation Wuhan 430070 China
3. College of Food Science and Engineering National Engineering Research Center of Wheat and Corn Further Processing Henan University of Technology Zhengzhou 450001 China
Abstract
AbstractWounds at joints are difficult to treat and tend to recover more slowly due to the frequent motions. When using traditional hydrogel dressings, they are easy to crack and undergo bacterial infection, difficult to match and monitor the irregular wounds. Integrating multiple functions within a hydrogel dressing to achieve intelligent wound monitoring and healing remains a significant challenge. In this research, a multifunctional hydrogel is developed based on polysaccharide biopolymer, poly(vinyl alcohol), and hydroxylated graphene through dynamic borate ester bonding and supramolecular interaction. The prepared hydrogel not only exhibits rapid self‐healing (within 60 s), injectable, conductive and motion monitoring properties, but also realizes in situ bacterial sensing and killing functions. It shows excellent bacterial sensitivity (within 15 min) and killing ability via the changes of electrical signals and photothermal therapy, avoiding the emergence of drug‐resistant bacteria. In vivo experiments prove that the hydrogel can promote wound healing effectively. In addition, it displays great electromechanical performance to achieve real‐time monitoring and prevent re‐tearing of the wound at human joints. The injectable pH‐responsive hydrogel with good biocompatibility demonstrates considerable potential as multifunctional bioelectronic dressing for the detection, treatment, management, and healing of infected joint wounds.
Funder
National Natural Science Foundation of China
Cited by
15 articles.
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