Affiliation:
1. Department of Cariology and Endodontics Nanjing Stomatological Hospital Medical School of Nanjing University Nanjing Jiangsu 210008 P. R. China
2. School of Marine Science and Technology Tianjin University Tianjin 300072 P. R. China
3. College of Engineering and Applied Sciences Nanjing National Laboratory of Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University Nanjing Jiangsu 210023 P. R. China
4. School of Chemical Engineering and Technology Tianjin University Tianjin 300072 P. R. China
5. State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center (ChemBIC) Nanjing University Nanjing Jiangsu 210023 P. R. China
Abstract
AbstractThe use of oxidoreductase nanozymes to regulate reactive oxygen species (ROS) has gradually emerged in periodontology treatments. However, current nanozymes for treating periodontitis eliminate ROS extensively and non‐specifically, ignoring the physiological functions of ROS under normal conditions, which may result in uncontrolled side effects. Herein, using the MIL‐47(V)‐F (MVF) nanozyme, which mimics the function of glutathione peroxidase (GPx), it is proposed that ROS can be properly regulated by specifically eliminating H2O2, the most prominent ROS. Through H2O2 elimination, MVF contributes to limiting inflammation, regulating immune microenvironment, and promoting periodontal regeneration. Moreover, MVF stimulates osteogenic differentiation of periodontal stem cells directly, further promoting regeneration due to the vanadium in MVF. Mechanistically, MVF regulates ROS by activating the nuclear factor erythroid 2‐related factor 2/heme oxygenase 1 (Nrf2/HO‐1) pathway and promotes osteogenic differentiation directly through the phosphatidylinositol 3‐kinase/protein kinase B (PI3K/Akt) pathway. A promising periodontitis therapy strategy is presented using GPx‐mimicking nanozymes through their triple effects of antioxidation, immunomodulation, and bone remodeling regulation, making nanozymes an excellent tool for developing precision medicine.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
1 articles.
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