Affiliation:
1. Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration International Joint Laboratory on Regeneration of Bone and Soft Tissues Guangxi Key Laboratory of Regenerative Medicine Collaborative Innovation Center of Regenerative Medicine and Medical Biological Resources Development and Application The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 P. R. China
2. Department of Orthopedics The Ninth Affiliated Hospital of Guangxi Medical University Beihai Guangxi 536000 P. R. China
3. Department of Orthopaedics Trauma and Hand Surgery The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 P. R. China
4. Pharmaceutical college Guangxi Medical University Nanning Guangxi 530021 P. R. China
Abstract
AbstractDue to the limited therapeutic efficacy of current treatments, articular cartilage regeneration is still challenging work. Scaffold‐based tissue engineering provides a promising strategy for cartilage regeneration, but most scaffolds are limited by poor mechanical properties or unfavorable biocompatibility. Here, a novel photocrosslinkable, injectable locust bean gum (LBG)–methacrylate (MA) hydrogel is reported as a biomimetic extracellular matrix (ECM) for cartilage repair with minimal invasive operation. LBG‐MA hydrogels show controllable degradation rate and improve mechanical properties and excellent biocompatibility. More importantly, LBG‐MA hydrogel significantly induces bone mesenchymal stem cells to chondrogenic differentiation in vitro, as evidenced by high accumulation of cartilage‐specific ECM components glycosaminoglycan and upregulated expression of key chondrogenic genes (collagen type II, aggrecan, and sex determining region Y‐box9). Besides, the hydrogel is injectable, which can be in situ crosslinked via UV irradiation. Further, the photocrosslinkable hydrogels accelerate cartilage healing in vivo after 8 weeks of therapy. A strategy is provided here for photocrosslinkable, injectable, biodegradable scaffold fabrication based on native polysaccharide polymer for minimal invasive cartilage repair.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Guangxi Province
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
9 articles.
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