Affiliation:
1. International Joint Research Center for Photo‐responsive Molecules and Materials School of Chemical and Material Engineering Jiangnan University Wuxi Jiangsu 214122 China
2. Department of radiology Affiliated Hospital of Jiangnan University Wuxi Jiangsu 214122 China
3. Jiangsu Institute of Parasitic Diseases Wuxi Jiangsu 214122 China
Abstract
AbstractAntibacterial photodynamic therapy (APDT) has emerged as one of the intriguing strategies to combat bacterial resistance. However, the antibacterial efficacy of APDT is found to be severely impacted by the hydrogen sulfide (H2S)‐overproduced bacterial infection microenvironment. Herein, a multifunctional APDT platform is developed by assembling Cu2+ and chlorin e6 (Ce6), which exhibits unique H2S‐activatable fluorescence (FL) and antibacterial features. Noteworthily, the assembly conditions are crucial for achievement of Cu‐Ce6 nanoassemblies (NAs) with the on‐demand responsive properties. The quenched FL and photosensitization of Cu‐Ce6 NAs can be selectively activated by the overexpressed H2S in infected area, enabling specific recognition of bacterial infection and localized antibacterial therapy with minimized side effects. Significantly, amplified oxidative stress is achieved owning to the effective consumption of H2S by Cu2+ in the NAs, leading to an enhanced APDT. The antibacterial mechanisms including broad‐spectrum APDT activity of released Ce6, inherent sterilization effects of produced copper polysulfides and the accompanying disturbance of bacterial sulphide metabolism are further identified. This study may pave a new avenue for the rational design of intelligent APDT platform using minimalist biological building units and thus facilitating the clinical translation of nano‐antibacterial agents.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Cited by
1 articles.
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