Water‐Responsive Self‐Contractive Silk‐Based Skin Anti‐Aging Tensioners with Customizable Biofunctions

Author:

Xie Yating12,Geng Lele34,Ni Siyuan1,Ni Wei5,He Ruizhe34,Liu Tiantian34,Zhang Gai6,Tao Tiger H.12789,Liu Keyin1,Peng Yinbo34ORCID

Affiliation:

1. State Key Laboratory of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China

2. School of Physical Science and Technology ShanghaiTech University Shanghai 200031 China

3. Department of Burns and Plastic Surgery & Department of Plastic Surgery and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 201900 China

4. Institute of Traumatic Medicine of Shanghai Jiao Tong University School of Medicine Shanghai 201900 China

5. Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology 1037 Luoyu road Wuhan 430000 China

6. Department of Burn Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 201900 China

7. Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China

8. Institute of Brain‐Intelligence Technology Zhangjiang Laboratory Shanghai 200031 China

9. Shanghai Research Center for Brain Science and Brain‐Inspired Intelligence Shanghai 200031 China

Abstract

AbstractSkin anti‐aging treatments have become increasingly popular. Currently, the prevalent treatment method involves implanting skin tension regulation threads (skin lifting threads) under the skin, and radiofrequency treatments. In this study, inspired by the natural supercontraction of spider silk, the molecular structure of silk fibroin fibers is modulated into an oriented configuration. This modification endows silk proteins with water‐responsive self‐contraction capabilities, leading to the development of innovative self‐contracting silk‐based skin tensioners (SSSTs). To align with clinical requirements, skin tension regulation materials are functionalized by testing for their self‐contraction, near‐infrared laser heating function, and bacteriostatic properties. The SSSTs exhibited remarkable self‐contraction properties, drug‐loading and sustained‐release capabilities, notable antibacterial effects, controllable degradation, and good biocompatibility. Moreover, the near‐infrared light heating function effectively increased subcutaneous temperature, demonstrating its potential for enhancing and prolonging skin lifting effects. Therefore, SSSTs can be applied for skin tension regulation to improve and delay skin aging. The results may pave the way for novel strategies in skin rejuvenation, with broad implications for the field of skin anti‐aging.

Publisher

Wiley

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