Injectable Mesh‐Like Conductive Hydrogel Patch for Elimination of Atrial Fibrillation

Author:

Dai Jing1,Wang Bingfang1,Chang Zhiqiang1,Lu Xinxin1,Nie Jianfang1,Ren Qinjuan1,Lv Yingying2,Rotenberg Menahem Y.3,Fang Yin1ORCID

Affiliation:

1. Research Center for Translational Medicine Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital The Institute for Biomedical Engineering & Nano Science Tongji University School of Medicine Shanghai 200120 China

2. Research Centre of Nanoscience and Nanotechnology College of Science Shanghai University Shanghai 200444 China

3. Department of Biomedical Engineering, Technion – Israel Institute of Technology Haifa 32000 Israel

Abstract

AbstractIrregular electrical impulses in atrium are the leading cause of atrial fibrillation (AF), resulting in fatal arrhythmia and sudden cardiac death. Traditional medication and physical therapies are widely used, but generally suffer problems in serious physical damage and high surgical risks. Flexible and soft implants have great potential to be a novel approach for heart diseases therapy. A conductive hydrogel‐based mesh cardiac patch is developed for application in AF elimination. The designed mesh patch with rhombic‐shaped structure exhibits excellent flexibility, surface conformability, and deformation compliance, making it fit well with heart surface and accommodate to the deformation during heart beating. Moreover, the mechanical elastic and shape‐memory properties of the mesh patch enable a minimally invasive injection of the patch into living animals. The mesh patch is implanted on the atrium surface for one month, indicating good biocompatibility and stability. Furthermore, the conductive patch can effectively eliminate AF owing to the conductivity and high charge storage capability (CSC) of the hydrogel. The proposed scheme of cardiac bioelectric signal modulation using conductive hydrogel brings new possibility for the treatment of arrhythmia diseases.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Fundamental Research Funds for the Central Universities

Publisher

Wiley

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