Affiliation:
1. School of Science Harbin Institute of Technology (Shenzhen) 518055 Shenzhen China
2. School of Chemistry and Chemical Engineering Harbin Institute of Technology 150001 Harbin China
3. Marshall Laboratory of Biomedical Engineering Precision Medicine and Health Research Institute School of Biomedical Engineering Health Science Center Shenzhen University 518060 Shenzhen China
Abstract
AbstractMitochondria‐targeted therapeutics are an attractive approach against energy‐dependent cancer. However, effective mitochondria organelle therapeutics agents are still highly desirable. Herein, a mitochondria‐targeted therapeutics platform, termed CDM@MUiO‐DP@MCHM, consisting of macrophages‐cancer hybrid membrane (MCHM) encapsulated MUiO‐66 metal−organic frameworks (MOFs) is reported, which is loaded with microRNA (miRNA) biomarker detection probe (DP) for cancer diagnosis and copper‐depleting moiety (CDM) for mitochondrial copper depletion to suppress cancer growth. Using nude mice bearing MCF‐7 as model, after injecting intravenously via the caudal vein of mice, the encapsulation of MCHM can not only greatly enhance the cancer homing‐targeting ability of the nanoparticles (NPs) but also endows the NPs the immune escape capacity to extend the circulation time. The miRNA‐21 biomarker can be detected by the fluorescence signal for diagnosis, while the CDM induced energy deficiency and compromised mitochondria membrane potential, leading to apoptosis of the cancer cell. The good performance of CDM@MUiO‐DP@MCHM suggest the great potential mitochondria organelle therapeutics.
Funder
National Natural Science Foundation of China
Shenzhen University
Subject
Pharmaceutical Science,Biomedical Engineering,Biomaterials
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献